A head-on collision on Route 25A in Wading River last night injured three people, one of them seriously, according to Riverhead Town Police.

Police said a 2014 Toyota 4Runner operated by Debra O’Connor, 46, of Calverton was westbound on Route 25A last night at about 7:20 p.m., crossed into the oncoming lane of travel and collided head-on with an eastbound 2004 Infiniti operated by Jean Derespina, 56, of Miller Place. Derespina’s husband, Frank, 56, was a front-seat passenger in the Infiniti.

A third vehicle, an eastbound 2003 Chevrolet Suburban operated by Frank Pendl, 49, of Rocky Point, swerved to avoid the accident and left the roadway, crashing into several trees, police said. His wife, Deborah, 48, was a passenger in the Suburban.

Jean Derespina was transported by Wading River Fire Department Rescue to Stony Brook Hospital with serious injuries, police said.

Debra O’Connor and Frank Derespina were also transported to Stony Brook and were treated for non-life-threatening injuries, according to police.

A heavy rescue unit from Wading River Fire Department responded to extricate Jean Derespina from her vehicle. A second heavy rescue unit from Riverhead Fire Department was called to extricate a second victim.

Riverhead Volunteer Ambulance was also called on mutual aid to transport one of the patients to Stony Brook.

Frank and Deborah Pendl were not injured in the accident.

The New York State Police Accident Reconstruction Team responded to the scene and are assisting with the investigation, which is ongoing, police said.

No arrests were made following the crash.

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